Fa'amatalaga o oloa
1. Uiga Oloa
Fa'afaigaluega Autu:
Paeoniflorin ( Sili atu pe tutusa ile 40%): Autu e -a'i fa'ama'i ma le neuroprotective agent
Aofa'i Monoterpene Glycosides ( Sili atu pe tutusa ile 80%): E aofia ai le oxypaeoniflorin, benzoylpaeoniflorin
Polyphenols: Galic acid, ellagic acid (antioxidant)
Polysaccharides (5-10%): Immunomodulatory galuega
Punavai Botanical: A'a mago o Paeonia lactiflora Pall. (Ranunculaceae)
Meatotino Faaletino: Pa'epa'e -pa'epa'e i le enaena mama, oona teisi, solu le vai
Fa'amatalaga:
Metala mamafa (Pb, Cd, As)<5ppm
Toega o vailaau fa'asaina o lo'o tausisia le CP2020
HPLC fa'atusatusaga o paeoniflorin (RSD<2%)
2.Product Profile
Fa'ata'ita'iga fa'ata'ita'iga maua e ala ile -maualalo fa'aoso fa'afeagai su'ega, fa'aalia:
Tolu Galuega Autu:
Tete'e-Fula ma Fa'amamago:
COX-2 fa'alavelave (IC50=3.2μM)
Fa'aitiitia le maualuga o le TNF- /IL-6 (ma'i ↓35%)
Neuroprotection:
Fa'agaoioia le ala BDNF (fa'aleleia le popole/mafaufau)
Fa'aititia -amyloid deposition (e aoga i fa'ata'ita'iga a le Alzheimer)
Tulafono Fa'atonu:
Fa'aitiitia le fa'ama'i muamua (50%↓ togi VAS)
Fa'asa'o le fa'aogaina ole estrogen (ER- / paleni)
Fa'amanuiaga vs NSAIDs:
✓ Leai se GI ita (COX-1 fa'asaoina)
✓ -lua -tulaga fa'aletonu fa'aletonu (Paleni Th1/Th2)
✓ Monographed i Saina Pharmacopoeia (CP) ma Iapani Pharmacopoeia (JP)
Su'esu'ega Fa'atekinisi
|
Fa'agasologa |
Fa'afouga Autu |
QC Tulaga |
|
Maualalo-vevela fa'asagatau fa'afefe |
Puipuia mea fa'agata (thermolabile compound) (<45°C) |
UPLC-QTOF atoa-su'e tamatamai lima |
|
Fa'amamāina lomitusi mole |
Paeoniflorin purity >95% |
Su'ega UV (λ=230nm) |
|
Polysaccharide timu vaega ninii |
Fa'atamaoaigaina 10-50kDa vaega ninii toaga |
Phenol-sufuric acid su'ega |
|
Sausau-mago microencapsulation |
Fa'aitiitia le hygroscopicity (susū<5%) |
36-masina fa'avavevave su'ega mautu |
Tulaga Tauvaga
Fa'amaoniga-Fa'avae:
Lisi ile WHO Resitala Fa'afomai Fa'aleaganu'u (mo le dysmenorrhea/flammation)
32 RCTs (e aofia ai faʻataʻitaʻiga o le vaega II fibromyalgia)
Fa'amatalaga Saogalemu:
LD50 >15g/kg (o'ona mata'utia o isumu)
Leai ni a'afiaga o le estrogenic (talafeagai mo -fa'aoga umi)
Maumau:
24-masina fa'aola (alumini laminate afifi)
Gastric acid-resistant (>90% taofi ile pH2 mo le 2h)
Talosaga
① Falema'i
Fua faaumiumi: Papa -tu'i e ufiufi (500mg ma le 200mg paeoniflorin)
Fa'ama'i Neurodegenerative: Ata ata (fa'atasi ma huperzine A)
② Soifua Maloloina o Tina
Dysmenorrhea fesoasoani: Pa'i vevela (fa'atasi ma le suau'u Angelica)
Lagolago mo le fa'ato'aga: Phytoestrogen complexes (fa'atasi ai ma cohosh uliuli)
③ Mea'ai Fa'atino
Lagolago lagona: GABA-meainu tu'ufa'atasi
Tausiga soofaatasi: Ituaiga II collagen pa'u fa'afefiloi
④ Cosmeceuticals
Sua -tetee mumu: Togafitiga o le Rosacea (0.5% le fa'asalaina)
Anti-glycation: Maanuminumi essences (fa'asa le fa'atupuina o AGEs)
⑤ Soifua Maloloina o Manu
Fa'ato'ato'a fagafao: Lamu le popole o taifau
Fa'ato'aga: Mea fa'apipi'i -tete'e mo i'a fa'ato'aga
Va'aiga Maketi
O le maketi o le gataifale -i le lalolagi atoa e oo atu i le $8.7B i le 2025. Fautuaga atinae:
Fa'atatau i le Tiliva:
Fai'ai-naanoparticles (BBB penetration)
Colon-fa'asa'o fa'apitoa (mo IBD)
Fuafuaga Synergistic:
Tu'ufa'atasiga fa'ama'i (gut-fai'ai-uterus axis modulation)
Fa'atasiga Mea Fa'afoma'i:
Fa'amau fa'ama'i (transdermal delivery)
Fa'ailoga mana'oga: "Fa'aeteete a'o ma'itaga" (fa'asa masani)
Avanoa avanoa: Paeoniflorin togi (40%/60%/90%)
Tausi:
Chinese Pharmacopoeia 2020
EU Traditional Herbal Medicinal Products Directive
Mo COA faʻapitoa poʻo le faʻamaonia o metotia, faʻafesoʻotaʻi la matou vaega faʻapitoa.
Fa'aputuina & Teuina
- afifiina: 1kg/pepa pepa pepa, 25kg/fiber pa'u (fa'atonu)
- Teuina: Teu i se nofoaga malulu, matutu, faʻamau ma puipuia mai le malamalama
- Ola Fa'asao: 24 masina (i lalo o tulaga e le'i tatalaina)
Tasi le tautua
Mea Mata → Paʻu → Aveese → Faʻauma OEM Products
Fa'asao 20% ile tau, Su'esu'eina Tulaga!
Hot Tag: pa'epa'e peony a'a pu'e, Saina pa'epa'e peony a'a fa'atau oloa, fale gaosimea
