Le Digestive Puipuiga Mealilo o Magnolia Extract
E maua mai i le pa'u o le vao a Saina o le Magnolia officinalis, o suʻesuʻega faʻaonaponei ua faʻaalia ai o loʻo i ai mea faʻapitoa e pei o.magnololmahonokiol. E fa'afefea ona galulue fa'atasi nei vaega e avea ma leoleo fa'anatura o le faiga o mea'ai?
Tolu Mechanisms Autu Faamalamalamaina
Aisea e fa'amama ai le manava ga'o?
Fa'agaoioi le GABA-B e fa'afefeteina le tele o maso lamolemole o le intestinal (75% le fua o le ma'ema'e ua matauina ile falema'i)
Poloka ala o le calcium e faʻaitiitia ai le teteʻe o maso o le intestinal (60% faʻaititia i le faʻaitiitia o le faʻalavelave i vitro)
E fa'afefea ona tete'e atu i le papala?
Taofi le fa'aliloina ole gatric acid: Fa'aitiitia le gaioiga H+/K+-ATPase (45% fa'alavelave pamu proton)
Fa'aleleia le puipuiga o le mucosal gastric: Fa'aosofia le fa'alilo o le prostaglandin E2 (fa'ateleina fa'atupu fa'a 3-5)
Anti-H. pylori action: Faʻalavelaveina biofilms siama (82% fua faʻaumatia)
O le a le mea e fa'atulafonoina ai le microbiota gut?
Faʻateleina le tuputupu aʻe o le bifidobacterium (2-3 faʻateleina faʻateleina)
Taofi fa'ama'i pei o le C. difficile (15-18mm le lautele o le sone fa'asaina)
Fa Fa'amanuiaga Fa'amaonia Fa'afoma'i
Dyspepsia galue
68% faʻaitiitiga i le epigastric tumu
72% faʻaleleia i le vave maʻona
Fa'ama'i itaitagofie (IBS)
55% fa'aitiitiga o le tiga o le manava
60% faʻaleleia i le faʻaogaina masani o le manava
Togafiti faaopoopo o le ma'i o le gastric
40% fa'avaveina le fa'amaloloina o le papala
50% maualalo le fua o le toe faia
Antibiotic-Associated Diarrhea
65% fa'aitiitiga o fa'alavelave
50% fa'apu'upu'u taimi toe fa'aleleia ole microbiota
Fa'asaienisi Taiala Filifilia e ala ile Fa'atulagaina
|
Tulaga |
Pepa Fautuaina |
Fa'atotonuga |
Fuafuaga |
Vasega |
|
Fa'atiga Matu'i le Gastric |
Fa'asa'o vave- Capsules |
30% magnolol |
200mg pe a manaʻomia |
PRN |
|
Tulafono Fa'atonu |
Papama'a ua ufiufi -enteric |
20% honokiol |
100mg TID |
4-8 vaiaso |
|
Gut Dysbiosis |
Probiotic Complex |
5% magnolol + probiotics |
1 pepa i aso taitasi |
12 vaiaso |
Fa'atonuga Fa'aoga Taua
⚠ O ai e tatau ona fa'aeteete?
Tina ma'itaga (e ono afaina ai maso lamolemole o le manava)
Ma'i ma'i ma'i toto (a'afiaga maualalo-toto maualalo)
⚠ Lapataiga o Fegalegaleaiga o Vailaau
Fa'aola mea fa'amalie (mana'omia le fetuunaiga o fua)
E ono a'afia ai vaila'au fa'ama'i (monitor INR)
Tolu Tulaga Auro mo Tulaga Lelei
① Aofa'i magnolol+honokiol Sili atu pe tutusa ile 25% (HPLC fa'amaonia)
② Pa'u -e maua mai (5-8× sili atu le gaioi nai lo la'au su'ega)
③ Fa'amalieina tapula'a mo vaila'au fa'ama'i (CFU<100/g)
Fa'amatalaga Fa'aoga
"O o'u tausaga o le IBS fula ua matua fa'aleleia atili ina ua uma le 2 vaiaso" - 32ioe tagata faigaluega ofisa
"O le saoasaoa o lo'u ma'i papala na faateia ai la'u foma'i ma'i" - 45yo executive
Su'esu'ega Fa'ainisinia
Utu -Fa'asuiga Axis Fai'ai(Su'esu'ega fou)
A'afia CNS e ala ile neura vagus
Fa'aiti'itia visceral hypersensitivity (35% maualuga le fa'ailoga o le tiga)
Gut Barier Toe faaleleia(Su'esu'ega manu)
2x fa'atuputeleina le polotini so'o fufusi ZO-1
40% faʻaitiitiga i le serum endotoxin maualuga
O le a le mea e tulaga ese ai le Magnolia Extract?
Fa'atusatusa ile -fuala'au GI e tasi, ole magnolia extract e galue ile:
Feso'ota'i -vaega e tele (magnolol + honokiol)
Tele-fa'agaioiga (neura + maso lamolemole + microbiota)
Fa'atonuga e lua (paleni le hyper/hypo-gaioiga)
