1. Fa'asinomaga Molecular
Oleuropein ole asecoiridoid glycosidetulaga ese maua i:
Lau olive (6-9% o lo'o i totonu)
Su'u olive taupou fa'aopoopo (aemaise lava le vave-seleni)
Epidermis fua olive
Leneiphenolic oonafa'amatala fa'atasi leSone lanumoanamanuia o le umi o lo'o matauina i tagata Metitirani.
2. Tolu -Mechanisms Action
A'afiaga o le cardioprotective:
Fa'aleleiaeNOS fa'agaoioia(300% LEAI fa'ateleina)
Fa'anaturaACE inhibitor(poka angiotensin)
Mitochondrial Mastery:
AMPK phosphorylation ↑150%
Lavelave I/III lelei +35%
Epigenetic Modulation:
SIRT1 fa'aaliga ↑2.1-papa
NF-κB taofiofia (IL-6 ↓60%)
3. Tulaga Auro Falemai
Polokalama fa'amaoni:
HPLC-TAMAmo oleuropein aglycone
NMRfaʻamaoniga o le fausaga mole
LC -MS/MS purity verification (>98%)
Tulaga Mautū:
pH 5.2-6.8 vaifofo vai
Avoid >60 tikeri faagasologa
E taua le afifiina o tioata pogisa
4. Pharmacokinetics Fa'atosina
Faiga Fa'atauga Tala:
Cyclodextrin lavelave(vai solubility ↑900%)
Transdermal patch(72-itula fa'asa'olotoga tumau)
Nanoemulsions sublingual(Tmax<15min)
Auala Metabolite:
→ Hydroxytyrosol (pepa galue)
→ Oleacein (anti-inflammatory)
→ Elenolic acid (antimicrobial)
