Aisea ua avea ai le Su'ega o La'au Mulberry o se tagata poto faapitoa i le fa'atonutonuina o le fa'aogaina o le kulukose?

1. Botanical Background & Traditional Use

O lau la'au mulberry (Morus alba L.) e iai:

1-Deoxynojirimycin (DNJ)(0.1-0.3%) - malosi -glucosidase inhibitor

Flavonoids(quercetin, isoquercitrin)

Polyphenols(chlorogenic acid, rutin)

Fa'amaumauga fa'asolopito:

O le Compendium of Materia Medica o lo'o fa'amauina ana mea e tete'e-i le ma'i suka

"Ti ma'isuka-tau lauti" masani a Iapani

2. Vaega Autu & Mechanisms

2.1 Fa'atonuga o le Metabolism Kulukose

2.2 Bioactives & Targets

3. Tulaga Tulaga Lelei

3.1 Fa'amaoni

Microscopy: Uiga uiga ese -fulu ivi ma fa'avae fulafula

TLC tamatamai lima: 5 nofoaga ma'oti e mana'omia

HPLC fa'atusatusaga: Sili atu pe tutusa ma le 0.1% DNJ (Pharmacopoeia standard)

3.2 Fa'amatalaga Fa'aonaponei

Chinese Pharmacopoeia: Aofa'i flavonoids Sili atu pe tutusa ile 1.5%

Tulaga Iapani: DNJ Sili atu pe tutusa ile 0.15%

Tulafono Faatonutonu a le EU: Toega o vailaau e tineia ai manu faalafua<0.01ppm

4. Fa'amatalaga Fa'afoma'i

4.1 Puleaina o le Ma'isuka

Ituaiga II DM: 1200mg/day fa'aitiitia HbA1c ile 0.8-1.2%

Prediabetes: NNT=8 e puipuia ai le alualu i luma o le ma'i suka

4.2 Aafiaga Metabolic

Lipid tulafono faatonutonu: 15-20% fa'aitiitia triglyceride

Puleaina o le mamafa: 2-3cm le li'o o le puimanava fa'aitiitia (12 vaiaso)

5. Fa'aoga lelei

5.1 Fuafuaga Fuafuaga

Fa'avae: 300mg (30min a'o le'i-aiga)

Malosi: 600mg + chromium combo

5.2 Tu'ufa'atasiga Fa'atasi

Gymnema sylvestre: Fa'aleleia le fa'aosoina ole inisalini

Alpha-lipoic acid: Fa'aleleia atili le fa'aogaina o le kulukose i totonu

Probiotics: Fa'asalaina le gut-tu'i o le pancreas

6. Manatuga mo le Saogalemu

Aafiaga o le hypoglycemia: Manaomia le mataituina ma antidiabetics

Ma'i tipitipi: Fa'agata le 1 vaiaso a'o le'i-fa'aoga

ma'ale'ale GI: Amata i tui maualalo

7. Taiala Filifiliga Oloa

Oloa Fa'apitoa Fa'apitoa:

Fa'ailoga DNJ anotusi

Maualalo-su'ega vevela

Lipoti o su'ega u'amea mamafa

Mataupu masani:

Suiga i ituaiga maualalo-DNJ

Fa'afoliga DNJ fa'akomepiuta

8. Su'esu'ega tuaoi

Microbiota o le gutu: Faʻateleina le tele o Akkermansia

NAFLD faʻaleleia: Taofi sela stellate ate

Fuafuaga -fa'asa'oloto: Fa'aumi le gaioiga DNJ

Fa'ai'uga Fa'asaienisi

Ole fua ole la'au mulberry e maua ai:
1️⃣ Tele-tulafono fa'atonu(gut + ate + aano o le tino)
2️⃣ Saogalemu faanatura(2000-tausaga le tala faasolopito)
3️⃣ Fa'amanuiaga fa'ato'a atoatoa(glucose+lipids+weight)